Inhibition of STAT3 on lung cancer in model mice

Discovery of a new inhibitor of cancer cell growth factor STAT3

Lung cancer is one of the common cancers that cause death. Since there is no effective way to cure lung cancer caused by smoking so far, the exploration in this field is urgently needed.

Professor Beatrice Grabner et al. found that STAT3 has an important role in the inhibition of lung cancer in model mice. The findings were published in the March 2015 issue of Nature Communications.

In-depth study of activated signaling pathways can serve as a new approach to targeted treatment of lung cancer, and this signaling pathway may become a potential new therapeutic approach in the future. Blocking the transmission of the transcription factor STAT3, which accelerates cancer cell growth in a variety of cancers (eg, leukemia, rectal cancer), has become a clinically important research direction.

Through Professor Grabner, Professor Casanova and foreign scientists at the Ludwig Boltzmann Cancer Institute in Vienna, we were surprised to find that STAT3 is important in inhibiting lung cancer in model mice. When the STAT3 signal is blocked, the rate of tumor deterioration accelerates.

b: Tumor cells were determined using CD31+ per mm2 of tumor area. At least 3 tumor areas in each model mouse were analyzed (4-7 mice replicates per group). The result is shown in the figure:

Quantitative analysis of tumor invasion, blood flow parameter analysis and detection of protein activity in lung cancer in cooperation with Austrian TissueGnostics, using TissueFAXS, HistoQuest and TissueQuest software. The article, published in the new journal Nature Communications, reveals that the safety of methods that rely on blocking STAT3 signaling to cure cancer remains to be confirmed, such as accelerating disease progression and reducing survival, so we need to take further attention to STAT3. And studies to determine the safety of STAT3 treatments.

Original link: http://

Contact company: AustriaTissueGnostics GmbH

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